Polynucleotides... everything you need to know.
- lisablackmore
- Mar 10
- 5 min read
Updated: Mar 14
Polynucleotides are a relatively recent addition to aesthetic treatments and have gained popularity due to their ability to promote bio-regeneration in the skin. When injected or microneedled in to the skin they facilitate repair and rejuvenation with minimal risk. While they don't provide immediate results, they can be safely applied to the face, scalp, and body and within a short time, provide fantastic improvements.
What are Polynucleotides?
Polynucleotides are naturally derived molecules that play a crucial role in stimulating cellular activity, promoting collagen production, and facilitating skin rejuvenation. Sourced from the DNA of salmon or trout sperm, these highly purified DNA fragments are suspended in water for to preserve them & make them usable for injections or microneedling.
How do they work?
Once injected, the DNA fragments are gradually absorbed into the skin. As they integrate, they signal the skin in three primary ways. First, they stimulate fibroblast cells to increase in number and enhance their activity. As cell renewal improves, so do collagen production, hydration levels, and skin radiance. The skin becomes more resilient with increased elasticity, and wrinkles begin to diminish.
Second, they act as potent antioxidants, eliminating free radicals that typically cause cellular damage. Third, they function as wound healing agents, prompting the skin to undergo intensive repair. This aids in improving scars, reducing stretch marks, and addressing skin texture issues. As the skin enters repair mode, discolouration improves (hyperpigmentaion reduces), resulting in a more even tone. Additionally, polynucleotides create a mild increase in volume and tightening as an overall effect.
The outcome of the treatment depends on several factors, including the extent of skin aging prior to the treatment, the skin’s capacity to regenerate high-quality tissue when stimulated, and lifestyle. However, they are extremely popular for very good reason and whatever your skin concerns an improvement can be achieved.
Where can Polynucleotides be used?
Polynucleotides have been proven to enhance skin texture and function, making them suitable for any skin area, including the scalp for promoting hair growth. We can focus on specific areas like the under-eye, forehead, or mouth, or treat the entire face. At Skin within we prefer to microneedle the entire face then use the Mesotherapy Technique to superficially inject concentration of product into areas of specific concern. Remember, they are not just for the face, on the body, they are commonly used for loose skin on the abdomen, above the knees, or on the inner arms.
Polynucleotides are often preferred for certain areas because they do not cause water retention like hyaluronic acid. In the under-eye region, polynucleotides can enhance skin strength and integrity instead tear trough treatment with dermal fillers. You will require a consultation & patch test before your treatment.
What does Polynucleotide treatment involve?
Polynucleotides are administered very superficially into the skin using two methods. They can be injected with extremely small needles, creating tiny blebs on the surface. These blebs typically disappear within a few hours, though they may persist longer for some individuals and bruising can occur. Alternatively, products can be microneedled into the skin which is particularly good for full face treatments, at Skin Within, Microneedling is usually part of all Skin Booster Treatments. It's important to remember, polynucleotides work at the cellular level, which takes time. While some improvement might be seen after 2-3 weeks, the full effect becomes apparent at 3 months.
Are Polynucleotides the same as Fillers?
No. Dermal fillers are composed of a gel with varying consistencies of hyaluronic acid. They primarily work through a physical volumising effect filling out the face. Dermal fillers provide an immediate result and continue to improve over the next 3-4 weeks & they typically last between 6-12 months.
Polynucleotides function differently. They promote cell regeneration, which means visible changes take time to appear but they are effectively repairing your skin for the longer term.
Polynucleotides at Skin Within
At the Skin Within Clinic we use a variety of Polynucleotides, I've described a couple of my favourites below.
Benefits and Uses
If you're seeking an effective way to rejuvenate and boost your skin's natural radiance, the Stayve Salmon DNA Gold is an innovative product to consider. Renowned for its powerful ingredients and its ability to enhance skin elasticity, hydration, and overall appearance, this ampoule is a must-have for advanced skincare routines.
This blog will delve into what makes the Salmon DNA Gold Ampoule unique, its key benefits, and how it can revolutionise your skincare regimen.
What Is Stayve Salmon DNA Gold Ampoule?
The Stayve Salmon DNA Gold Ampoule is a high-end skincare product crafted for professional use. It merges state-of-the-art biotechnology with luxurious ingredients to deliver outstanding results.
The main component is salmon DNA, which is rich in polynucleotides (PNs)—natural substances known for their ability to regenerate skin cells and aid in tissue repair. Paired with 24K gold particles, this ampoule offers both anti-aging and skin-brightening effects, leaving the skin looking youthful, radiant, and healthy.
Top Benefits of Salmon DNA Gold Ampoule
1. Boosts Skin Regeneration
Salmon DNA encourages cell regeneration and repair, helping to rejuvenate damaged skin, diminish acne scars, and smooth fine lines and wrinkles.
2. Hydration Powerhouse
Infused with ultra-hydrating ingredients, the ampoule replenishes the skin's moisture barrier, making it plump, supple, and glowing.
3. Brightens and Evens Out Skin Tone
The gold particles in the formula not only add a touch of luxury but also help brighten the skin and improve uneven pigmentation.
4. Fights Signs of Aging
This ampoule's anti-aging benefits enhance skin elasticity, reduce fine lines, and create a firmer, more youthful look.
5. Reduces Inflammation
Salmon DNA is recognised for its anti-inflammatory properties, making it perfect for calming irritated or sensitive skin.
A revolutionary bio-revitalising cocktail for the face, neck & décolletage, Derma Bio 2.0 is a medical grade skin booster. Containing 3 different weights of hyaluronic acid plus numerous individual active ingredients, Derma 2.0 Bio is the perfect treatment for all signs of aging. Skin Benefits? Improved tone, a more radiant & relaxed appearance, greater elasticity & firmness, significant reduction in fine lines & wrinkles, a more even skin tone, greater hydration & a smoother texture. A true anti-aging, restorative Skin Booster Due to the groundbreaking complex of 3 molecular weights of hyaluronic acid, Vitamins A, B, C & E, plus amino acids, Potent Firming Agent, peptides, sodium DNA & antioxidants acting in synergy, after just 4 weeks, there is a significant improvement to the skin & a brighter, relaxed & more uniform appearance.
So if you are interested in Polynucleotides near Peterborough, polynucleotides near Bourne or Polynucleotide therapy near Stamford, Lincolnshire please send a message.
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